Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study.

ABSTRACT:

Objective

To determine the ordering of changes in Alzheimer disease (AD) biomarkers among cognitively normal individuals.

Methods

Cross-sectional data, including CSF analytes, molecular imaging of cerebral fibrillar β-amyloid (Aβ) with PET using the [¹¹C] benzothiazole tracer Pittsburgh compound B (PiB), MRI-based brain structures, and clinical/cognitive outcomes harmonized from 8 studies, collectively involving 3,284 cognitively normal individuals 18 to 101 years of age, were analyzed. The age at which each marker exhibited an accelerated change (called the change point) was estimated and compared across the markers.

Results

Accelerated changes in CSF Aβ_1-42 (Aβ₄₂) occurred at 48.28 years of age and in Aβ₄₂/Aβ₄₀

SUBMITTER: Luo J 

PROVIDER: S-EPMC7734923 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature