Unverricht-Lundborg disease (EPM1) in Finland: A nationwide population-based study.

ABSTRACT:

Objective

To investigate the epidemiology and prognosis of Unverricht-Lundborg disease (EPM1) in a nationwide, population-based setting.

Methods

Data from multiple registries were combined and analyzed. Clinical data were obtained from medical records. All patients treated for EPM1 in Finland between January 1, 1998, and December 31, 2016 were included.

Results

A total of 135 persons with EPM1 (54% women) were identified and 105 were alive on December 31, 2016 (point prevalence 1.91/100,000 persons). The age-standardized (European Standard Population 2013) prevalence was 1.53/100,000 persons. Annual incidence during the study period was 0.022/100,000 person-years, with a mean age at onset of 9.4 ± 2.3 years (range 7.0-14.6 years, no sex difference). The median age at

SUBMITTER: Sipila JOT 

PROVIDER: S-EPMC7734927 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature