Antihypertensive drug effects according to the pretreatment self-measured home blood pressure: the HOMED-BP study.

ABSTRACT:

Objectives

To clarify whether or not the antihypertensive drug effect is proportional to the baseline pretreatment self-measured home blood pressure (HBP) in accordance with the law of initial value (Wilder's law).

Design

A post-hoc analysis of a multicentre clinical trial.

Setting

Outpatients across Japan with mild-to-moderate essential hypertension.

Participants

Among 3518 randomised participants, 2423 who self-measured HBP during the pretreatment drug-free period (10-28 days after starting fixed-dose antihypertensive monotherapy) with a mean 7.0 years follow-up were eligible.

Main outcome measures

We analysed individual HBP readings during pretreatment and monotherapy.

Results

The day-to-day HBP during both the pretreatment period and monothera

SUBMITTER: Sano H 

PROVIDER: S-EPMC7735093 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature