Effect of surfactant dose on outcomes in preterm infants with respiratory distress syndrome: the OPTI-SURF study protocol.

ABSTRACT:

Introduction

Respiratory distress syndrome is a condition seen in preterm infants primarily due to surfactant insufficiency. European guidelines recommend the dose and method of surfactant administration. However, in routine practice, clinicians often use a 'whole vial' approach to surfactant dosing. The aim of this study is to assess whether in preterm infants of gestational age 36⁺⁶ weeks^+days or less, a low first dose of surfactant (100-130 mg/kg) compared with a high first dose (170-200 mg/kg) affects survival with no mechanical ventilation on either on postnatal days 3 and 4, and other outcomes.

Methods and analysis

In this prospective, observational study, we will use the National Neonatal Research Database as the main data source. We will obtain

SUBMITTER: Goss KCW 

PROVIDER: S-EPMC7735095 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature