Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes.

ABSTRACT:

Background

In the current SARS-CoV-2 pandemic, there has been worldwide debate on the use of corticosteroids in COVID-19. In the recent RECOVERY trial, evaluating the effect of dexamethasone, a reduced 28-day mortality in patients requiring oxygen therapy or mechanical ventilation was shown. Their results have led to considering amendments in guidelines or actually already recommending corticosteroids in COVID-19. However, the effectiveness and safety of corticosteroids still remain uncertain, and reliable data to further shed light on the benefit and harm are needed.

Objectives

The aim of this systematic review and meta-analysis was to evaluate the effectiveness and safety of corticosteroids in COVID-19.

Methods

A systematic literature search of RCTS and observationa

SUBMITTER: van Paassen J 

PROVIDER: S-EPMC7735177 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature