Spatial structure maintains diversity of pyocin inhibition in household Pseudomonas aeruginosa.

ABSTRACT: Nearly all bacteria produce narrow-spectrum antibiotics called bacteriocins. Studies have shown that bacteriocins can mediate microbial interactions, but the mechanisms underlying patterns of inhibition are less well understood. We assembled a spatially structured collection of isolates of Pseudomonas aeruginosa from bathroom and kitchen sink drains in nine households. Growth inhibition of these P. aeruginosa by bacteriocins, known as pyocins in this species, was measured using pairwise inhibition assays. Carbon source usage of these isolates was measured, and genetic distance was estimated using multilocus sequencing. We found that as the distance between sites of isolation increased, there was a significantly higher probability of inhibition, and that pyocin inhibition and

SUBMITTER: Mojesky AA 

PROVIDER: S-EPMC7735282 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature