Decorating 3D Printed Scaffolds with Electrospun Nanofiber Segments for Tissue Engineering.

ABSTRACT: Repairing large tissue defects often represents a great challenge in clinics due to issues regarding lack of donors, mismatched sizes, irregular shapes, and immune rejection. 3D printed scaffolds are attractive for growing cells and producing tissue constructs because of the intricate control over pore size, porosity, and geometric shape, but the lack of biomimetic surface nanotopography and limited biomolecule presenting capacity render them less efficacious in regulating cell responses. Herein, a facile method for coating 3D printed scaffolds with electrospun nanofiber segments is reported. The surface morphology of modified 3D scaffolds changes dramatically, displaying a biomimetic nanofibrous structure, while the bulk mechanical property, pore size, and porosity are not significantly c

SUBMITTER: Li R 

PROVIDER: S-EPMC7735424 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature