Association between Vitamin D supplementation and mortality in critically ill patients: A systematic review and meta-analysis of randomized clinical trials.

ABSTRACT:

Background

Observational studies suggest that low 25-hydroxyvitamin D status is common and has been associated with higher mortality in critically ill patients. This study aim to investigate whether vitamin D supplementation is associated with lower mortality in critically ill patients.

Method

We searched Medline, Embase, and Cochrane databases from inception to January 12, 2020, without language restrictions, for randomized controlled trials comparing the effect of vitamin D supplementation with placebo in critically ill patients. Two authors independently performed data extraction and assessed study quality. The primary outcome was all-cause mortality at the longest follow-up.

Result

We identified nine trials with a total of 2066 patients. Vitamin D supplementation

SUBMITTER: Peng L 

PROVIDER: S-EPMC7735584 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature