A comparison of the effectiveness of functional MRI analysis methods for pain research: The new normal.

ABSTRACT: Studies of the neural basis of human pain processing present many challenges because of the subjective and variable nature of pain, and the inaccessibility of the central nervous system. Neuroimaging methods, such as functional magnetic resonance imaging (fMRI), have provided the ability to investigate these neural processes, and yet commonly used analysis methods may not be optimally adapted for studies of pain. Here we present a comparison of model-driven and data-driven analysis methods, specifically for the study of human pain processing. Methods are tested using data from healthy control participants in two previous studies, with separate data sets spanning the brain, and the brainstem and spinal cord. Data are analyzed by fitting time-series responses to predicted BOLD responses in o

SUBMITTER: Stroman PW 

PROVIDER: S-EPMC7735591 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature