Efficacy and safety of NOAC versus warfarin in AF patients with left atrial enlargement.

ABSTRACT:

Background

Little is known about the effects of anticoagulation in patients with atrial fibrillation (AF) and left atrial enlargement (LAE).

Methods

Data of patients with AF were retrieved from Chang Gung Research Database during 2007-2016. We excluded patients who were not using oral anticoagulants, used anticoagulants for <30 days, used ≥2 agents concomitantly or switched anticoagulants, had left atrial diameter missing from their data, were aged <65, had received valve surgeries, had mitral stenosis, or had a history of cancer. The primary outcomes were ischemic stroke (IS)/systemic embolism (SE), major bleeding, and death from any cause.

Results

We identified 40,777 patients who received a diagnosis of AF. After the exclusion criteria were applied, 6,445 patients

SUBMITTER: Wu VC 

PROVIDER: S-EPMC7735599 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature