Schistosoma haematobium infection is associated with alterations in energy and purine-related metabolism in preschool-aged children.

ABSTRACT: Helminths are parasitic worms that infect over a billion people worldwide. The pathological consequences from infection are due in part, to parasite-induced changes in host metabolic pathways. Here, we analyse the changes in host metabolic profiles, in response to the first Schistosoma haematobium infection and treatment in Zimbabwean children. A cohort of 83 schistosome-negative children (2-5 years old) as determined by parasitological examination, guardian interviews and examination of medical records, was recruited at baseline. Children were followed up after three months for parasitological diagnosis of their first S. haematobium infection, by detection of parasite eggs excreted in urine. Children positive for infection were treated with the antihelminthic drug praziquantel, and treatm

SUBMITTER: Osakunor DNM 

PROVIDER: S-EPMC7735607 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature