Recent advances in sarcoidosis genomics: epigenetics, gene expression, and gene by environment (G × E) interaction studies.

ABSTRACT:

Purpose of review

We aim to review the most recent findings in genomics of sarcoidosis and highlight the gaps in the field.

Recent findings

Original explorations of sarcoidosis subphenotypes, including cases associated with the World Trade Center and ocular sarcoidosis, have identified novel risk loci. Innovative gene--environment interaction studies utilizing modern analytical techniques have discovered risk loci associated with smoking and insecticide exposure. The application of whole-exome sequencing has identified genetic variants associated with persistent sarcoidosis and rare functional variations. A single epigenomics study has provided background knowledge of DNA methylation mechanisms in comparison with gene expression data. The application of machine-learning tech

SUBMITTER: Garman L 

PROVIDER: S-EPMC7735660 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature