Ontology highlight
ABSTRACT:
SUBMITTER: Klein IA
PROVIDER: S-EPMC7735713 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200601 6497
The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we investigated whether condensates concentrate small-molecule cancer therapeutics such that their pharmacodynamic properties are altered. We found that antineoplastic drugs become concentrated in specific protein condensates in vitro and that this occurs through physicochemical properties independent of the drug target. This behavior was als ...[more]