Ontology highlight
ABSTRACT:
SUBMITTER: Thompson MG
PROVIDER: S-EPMC7735754 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
eLife 20201203
Viral infection induces the expression of numerous host genes that impact the outcome of infection. Here, we show that infection of human lung epithelial cells with influenza A virus (IAV) also induces a broad program of alternative splicing of host genes. Although these splicing-regulated genes are not enriched for canonical regulators of viral infection, we find that many of these genes do impact replication of IAV. Moreover, in several cases, specific inhibition of the IAV-induced splicing pa ...[more]