Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.

ABSTRACT:

Background

The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies.

Methods

Germline DNA samples were sequenced for mutations in 23 cancer predisposition genes using a QIAseq multiplex amplicon panel. Prevalence of mutations and odds ratios (ORs) for associations with breast cancer risk were estimated with adjustment for study design, age, and family history of breast cancer.

Resul

SUBMITTER: Palmer JR 

PROVIDER: S-EPMC7735769 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature