The association between maternal lipid profile after birth and offspring risk of autism spectrum disorder.

ABSTRACT:

Purpose

Maternal obesity has been consistently associated with offspring risk for ASD, as well as lipid metabolism derangements. However, few ASD studies have examined maternal lipids in conjunction with maternal prepregnancy body mass index (BMI).

Methods

This nested case-control study was based on the Boston Birth Cohort, a prospective cohort study of mother-child dyads recruited at the Boston Medical Center. Maternal blood samples were collected shortly after delivery and analyzed for total plasma cholesterol, HDL, and triglyceride (TG) concentrations. Low-density lipoprotein (LDL) was subsequently calculated by the Friedewald equation. Cases were identified using ASD diagnoses in children's medical records. The odds of ASD were estimated with continuous lipid levels for

SUBMITTER: Park BY 

PROVIDER: S-EPMC7736082 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature