Prepregnancy handling of antineoplastic drugs and risk of miscarriage in female nurses.

ABSTRACT:

Purpose

To examine the association betweenantineoplastic drug (AD) handling and risk of miscarriage.

Methods

Nurses' Health Study-3 participants self-reported AD administration and engineering controls (ECs) and personal protective equipment (PPE) use at baseline. We estimated the hazard ratio (HR) of miscarriage in relation to baseline AD handling using multivariable Cox proportional regression.

Results

Overall, 2440 nurses reported 3327 pregnancies, with 550 (17%) ended in miscarriages. Twelve percent of nurses self-reported currently handling AD and 28% previously handling AD. Compared with nurses who never handled AD, nurses who handled AD at baseline had an adjusted HR of miscarriage of 1.26 (95% confidence interval [CI], 0.97-1.64). This association was stronger

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC7736108 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature