Exposure to polychlorinated biphenyls and organochlorine pesticides and thyroid cancer in connecticut women.

ABSTRACT:

Background

Thyroid cancer incidence has increased substantially over the past decades, and environmental risk factors have been suggested to play a role. Polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP) are established thyroid hormone disruptors, but their relationship to thyroid cancer is not known.

Methods

We investigated the relationship between serum PCB and OCP concentrations and papillary thyroid cancer (PTC) in 250 incident female PTC cases and 250 female controls frequency-matched on age, all residing in Connecticut. Interviews and serum samples were collected from 2010 to 2013. Samples were analyzed for 32 different chemicals using gas chromatography with isotope dilution high resolution mass spectrometry. We calculated odds ratios (OR) and 95% co

SUBMITTER: Deziel NC 

PROVIDER: S-EPMC7736223 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature