Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study.

ABSTRACT:

Objective

To assess whether women with a genetic predisposition to medical conditions known to increase pre-eclampsia risk have an increased risk of pre-eclampsia in pregnancy.

Design

Case-control study.

Setting and population

Pre-eclampsia cases (n = 498) and controls (n = 1864) in women of European ancestry from five US sites genotyped on a cardiovascular gene-centric array.

Methods

Significant single-nucleotide polymorphisms (SNPs) from 21 traits in seven disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal and thrombophilia) with published genome-wide association studies (GWAS) were used to create a genetic instrument for each trait. Multivariable logistic regression was used to test the association of each

SUBMITTER: Gray KJ 

PROVIDER: S-EPMC7736250 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature