Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines.

ABSTRACT:

Background

Aging-related cognitive decline is a primary risk factor for Alzheimer's disease and related dementias. More precise identification of the neurobiological bases of cognitive decline in aging populations may provide critical insights into the precursors of late-life dementias.

Methods

Using structural and diffusion brain magnetic resonance imaging data from the UK Biobank (n = 8185; age range, 45-78 years), we examined aging of regional gray matter volumes (nodes) and white matter structural connectivity (edges) within 9 well-characterized networks of interest in the human brain connectome. In the independent Lothian Birth Cohort 1936 (n = 534; all 73 years of age), we tested whether aging-sensitive connectome elements are enriched for key domains of cognitive func

SUBMITTER: Madole JW 

PROVIDER: S-EPMC7736316 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature