Genome-wide correlation analysis to identify amplitude regulators of circadian transcriptome output.

ABSTRACT: Cell-autonomous circadian system, consisting of core clock genes, generates near 24-h rhythms and regulates the downstream rhythmic gene expression. While it has become clear that the percentage of rhythmic genes varies among mouse tissues, it remains unclear how this variation can be generated, particularly when the clock machinery is nearly identical in all tissues. In this study, we sought to characterize circadian transcriptome datasets that are publicly available and identify the critical component(s) involved in creating this variation. We found that the relative amplitude of 13 genes and the average level of 197 genes correlated with the percentage of cycling genes. Of those, the correlation of Rorc in both relative amplitude and the average level was one of the strongest. In additi

SUBMITTER: Littleton ES 

PROVIDER: S-EPMC7736363 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature