Depletion but Activation of CD56^dimCD16⁺ NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus.

ABSTRACT: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality (12%-30%). The mechanism by which the SFTS bunyavirus (SFTSV) causes severe illness remains unclear. To evaluate the phenotypic and functional characteristics of the NK cell subsets in SFTS patients, twenty-nine SFTS patients were sequentially sampled from admission until recovery. Phenotypic and functional characteristics of NK cell subsets in circulating blood were analysed via flow cytometry. Then, correlations between NK cell subset frequencies and the SFTS index (SFTSI) were evaluated in all SFTS patients (15 mild, 14 severe) upon admission. The frequencies of CD56^dimCD16⁺ NK cells were greatly decreased in early SFTSV infection and were negatively correlated

SUBMITTER: Li M 

PROVIDER: S-EPMC7736421 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature