Combined quality and dose-volume histograms for assessing the predictive value of ^99mTc-MAA SPECT/CT simulation for personalizing radioembolization treatment in liver metastatic colorectal cancer.

ABSTRACT:

Background

The relationship between the mean absorbed dose delivered to the tumour and the outcome in liver metastases from colorectal cancer patients treated with radioembolization has already been presented in several studies. The optimization of the personalized therapeutic activity to be administered is still an open challenge. In this context, how well the ^99mTc-MAA SPECT/CT predicts the absorbed dose delivered by radioembolization is essential. This work aimed to analyse the differences between predictive ^99mTc-MAA-SPECT/CT and post-treatment ⁹⁰Y-microsphere PET/CT dosimetry at different levels. Dose heterogeneity was compared voxel-to-voxel using the quality-volume histograms, subsequently used to demonstrate how it could be used to identify

SUBMITTER: Levillain H 

PROVIDER: S-EPMC7736450 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature