Genome-wide association analysis of opioid use disorder: A novel approach using clinical data.

ABSTRACT:

Background

Opioid use disorder (OUD) represents a large and pervasive global public health challenge. Previous genetic studies have demonstrated the significant heritability of OUD and identified several single-nucleotide polymorphisms (SNPs) associated with its prevalence.

Methods

In this paper, we conducted a genome-wide association analysis on opioid use disorder that leveraged genetic and clinical data contained in a biobank of 21,310 patients of European ancestry. We identified 1039 cases of opioid use disorder based on diagnostic codes from nearly 16 million encounters in electronic health records (EHRs).

Results

We discovered one novel OUD-associated locus on chromosome 4 that was significant at a genome-wide threshold (p = 2.40 × 10^-8). Heritability

SUBMITTER: Song W 

PROVIDER: S-EPMC7736461 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature