In vivo observation and biophysical interpretation of time-dependent diffusion in human cortical gray matter.

ABSTRACT: The dependence of the diffusion MRI signal on the diffusion time t is a hallmark of tissue microstructure at the scale of the diffusion length. Here we measure the time-dependence of the mean diffusivity D(t) and mean kurtosis K(t) in cortical gray matter and in 25 ​gray matter sub-regions, in 10 healthy subjects. Significant diffusivity and kurtosis time-dependence is observed for t=21.2-100 ​ms, and is characterized by a power-law tail ∼t^-ϑ with dynamical exponent ϑ. To interpret our measurements, we systematize the relevant scenarios and mechanisms for diffusion time-dependence in the brain. Using the effective medium theory formalism, we derive an exact relation between the power-law tails in D(t) and K(t). The estimated dynamical exponent ϑ≃1/2 in both D(t) and K(t) is cons

SUBMITTER: Lee HH 

PROVIDER: S-EPMC7736473 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature