Adolescent Attention-Deficit/Hyperactivity Disorder: Understanding Teenage Symptom Trajectories.

ABSTRACT: Symptoms of attention-deficit/hyperactivity disorder (ADHD) run a variable course through adolescence. While most affected individuals show some improvement, particularly of hyperactivity-impulsivity, symptoms of inattention are more persistent, and some individuals may meet diagnostic criteria for the first time during adolescence. Genetic factors affect adolescent symptom trajectories; those showing persistence likely carry a greater burden of common risk alleles. Rare structural genomic variants, such as copy number variants and point mutations, might also play a role. Although psychostimulant medication is associated with better functional outcomes, an impact on underlying adolescent symptom trajectories has been hard to demonstrate. At a neural level, several studies report that adole

SUBMITTER: Shaw P 

PROVIDER: S-EPMC7736482 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature