Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia.

ABSTRACT: Myelination facilitates rapid axonal conduction, enabling efficient communication across different parts of the nervous system. Here we examined mechanisms controlling myelination after injury and during axon regeneration in the central nervous system (CNS). Previously, we discovered multiple molecular pathways and strategies that could promote robust axon regrowth after optic nerve injury. However, regenerated axons remain unmyelinated, and the underlying mechanisms are elusive. In this study, we found that, in injured optic nerves, oligodendrocyte precursor cells (OPCs) undergo transient proliferation but fail to differentiate into mature myelination-competent oligodendrocytes, reminiscent of what is observed in human progressive multiple sclerosis. Mechanistically, we showed that OPC-in

SUBMITTER: Wang J 

PROVIDER: S-EPMC7736523 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature