A review of available software for adaptive clinical trial design.

ABSTRACT:

Background/aims

The increasing cost of the drug development process has seen interest in the use of adaptive trial designs grow substantially. Accordingly, much research has been conducted to identify barriers to increasing the use of adaptive designs in practice. Several articles have argued that the availability of user-friendly software will be an important step in making adaptive designs easier to implement. Therefore, we present a review of the current state of software availability for adaptive trial design.

Methods

We review articles from 31 journals published in 2013-2017 that relate to methodology for adaptive trials to assess how often code and software for implementing novel adaptive designs is made available at the time of publication. We contrast our findings ag

SUBMITTER: Grayling MJ 

PROVIDER: S-EPMC7736777 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature