Identification of a differentiation stall in epithelial mesenchymal transition in histone H3-mutant diffuse midline glioma.

ABSTRACT:

Background

Diffuse midline gliomas with histone H3 K27M (H3K27M) mutations occur in early childhood and are marked by an invasive phenotype and global decrease in H3K27me3, an epigenetic mark that regulates differentiation and development. H3K27M mutation timing and effect on early embryonic brain development are not fully characterized.

Results

We analyzed multiple publicly available RNA sequencing datasets to identify differentially expressed genes between H3K27M and non-K27M pediatric gliomas. We found that genes involved in the epithelial-mesenchymal transition (EMT) were significantly overrepresented among differentially expressed genes. Overall, the expression of pre-EMT genes was increased in the H3K27M tumors as compared to non-K27M tumors, while the expression of po

SUBMITTER: Sanders LM 

PROVIDER: S-EPMC7736793 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature