Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses.

ABSTRACT: Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone supplementation would increase fetal progesterone, affect progesterone target tissues in the developing fetal reproductive system and be metabolised to other bioactive steroids in the fetus. We investigated the effects of progesterone treatment during early pregnancy on maternal and fetal plasma progesterone concentrations, transcript abundance in the fetal pituitary and testes and circulating steroids, at day 75 gestation, using a clinically reali

SUBMITTER: Siemienowicz KJ 

PROVIDER: S-EPMC7736841 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature