Yeast cell wall mannan rich fraction modulates bacterial cellular respiration potentiating antibiotic efficacy.

ABSTRACT: Now more than ever there is a demand to understand the mechanisms surrounding antibiotic resistance and look for alternative ways to impact phenotypic antibiotic outcome. Cellular energetics can be impacted by many bacteriostatic and bactericidal antibiotics, which affect metabolism and energy output, resulting in a reduction of cell growth or induction of cell death respectively. In this study, we provide evidence that a mannan rich fraction (MRF) from the cell wall of Saccharomyces cerevisiae modulates growth of antibiotic susceptible and resistant Escherichia coli and potentiates bactericidal antibiotic efficiency through modulation of bacterial cellular respiration. The role of MRF in modulating bactericidal impact and cellular metabolic state were assessed in E. coli by monitoring mic

SUBMITTER: Smith H 

PROVIDER: S-EPMC7736855 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature