Beige fat is dispensable for the metabolic benefits associated with myostatin deletion.

ABSTRACT:

Objective

Increasing muscle mass and activating beige fat both have great potential for ameliorating obesity and its comorbidities. Myostatin null mice have increased skeletal muscle mass and are protected from obesity and its sequelae. Deletion of myostatin has also been suggested to result in the activation of beige adipocytes, thermogenic fat cells with anti-obesity and anti-diabetes properties. It is not known whether beige fat activation contributes to the protection from obesity in myostatin null mice.

Methods

To investigate the role of beige fat activation in the metabolic benefits associated with myostatin deletion, we crossed myostatin null mice to adipocyte-specific PRDM16 knockout mice. We analyzed this new mouse model using molecular profiling, whole mount three-

SUBMITTER: Marchildon F 

PROVIDER: S-EPMC7736974 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature