Obesity Genes and Weight Loss During Lifestyle Intervention in Children With Obesity.

ABSTRACT:

Importance

Genome-wide association studies have identified genetic loci influencing obesity risk in children. However, the importance of these loci in the associations with weight reduction through lifestyle interventions has not been investigated in large intervention trials.

Objective

To evaluate the associations between various obesity susceptibility loci and changes in body weight in children during an in-hospital, lifestyle intervention program.

Design, setting, and participants

Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children (LOGIC), an interventional prospective cohort study, enrolled 1429 children with overweight or obesity to participate in an in-hospital lifestyle intervention program. Genotyping of 56 validated obesi

SUBMITTER: Heitkamp M 

PROVIDER: S-EPMC7737153 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature