Transcriptional Signatures That Define Ulcerative Colitis in Remission.

ABSTRACT:

Background

This study addresses whether existing specific transcriptional profiles can improve and support the current status of the definition of ulcerative colitis (UC) remission apart from the existing endoscopic, histologic, and laboratory scoring systems. For that purpose, a well-stratified UC patient population in remission was compared to active UC and control patients and was investigated by applying the next-generation technology RNA-Seq.

Methods

Mucosal biopsies from patients in remission (n = 14), patients with active UC (n = 14), and healthy control patientss (n = 16) underwent whole-transcriptome RNA-Seq. Principal component analysis, cell deconvolution methods, gene profile enrichment, and pathway enrichment methods were applied to define a specific transcripti

SUBMITTER: Fenton CG 

PROVIDER: S-EPMC7737162 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature