Potential of resveratrol in enrichment of neural progenitor-like cell induction of human stem cells from apical papilla.

ABSTRACT:

Introduction

Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease. Human stem cells from apical papilla (hSCAPs) are derived from migratory neural crest stem cells and exhibit a potential of neuronal differentiation. However, their neuronal differentiation is low and unpredictable. Resveratrol has been described as a sirtuin 1 (SIRT1) activator which plays an important role in enhancing neuronal differentiation. In this study, we investigate the potential of resveratrol as an enhancer on neuronal differentiation through NPCs induction of hSCAPs.

Methods

Stem cells were isolated from human apical papilla and characterized as MSCs. The cellular toxicity

SUBMITTER: Songsaad A 

PROVIDER: S-EPMC7737267 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature