AnnoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions.

ABSTRACT:

Background

Gene fusion events are significant sources of somatic variation across adult and pediatric cancers and are some of the most clinically-effective therapeutic targets, yet low consensus of RNA-Seq fusion prediction algorithms makes therapeutic prioritization difficult. In addition, events such as polymerase read-throughs, mis-mapping due to gene homology, and fusions occurring in healthy normal tissue require informed filtering, making it difficult for researchers and clinicians to rapidly discern gene fusions that might be true underlying oncogenic drivers of a tumor and in some cases, appropriate targets for therapy.

Results

We developed annoFuse, an R package, and shinyFuse, a companion web application, to annotate, prioritize, and explore biologically-relevant e

SUBMITTER: Gaonkar KS 

PROVIDER: S-EPMC7737294 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature