Convergent network effects along the axis of gene expression during prostate cancer progression.

ABSTRACT:

Background

Tumor-specific genomic aberrations are routinely determined by high-throughput genomic measurements. It remains unclear how complex genome alterations affect molecular networks through changing protein levels and consequently biochemical states of tumor tissues.

Results

Here, we investigate the propagation of genomic effects along the axis of gene expression during prostate cancer progression. We quantify genomic, transcriptomic, and proteomic alterations based on 105 prostate samples, consisting of benign prostatic hyperplasia regions and malignant tumors, from 39 prostate cancer patients. Our analysis reveals the convergent effects of distinct copy number alterations impacting on common downstream proteins, which are important for establishing the tumor phenotyp

SUBMITTER: Charmpi K 

PROVIDER: S-EPMC7737297 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature