Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in the object-based attention test in mice.

ABSTRACT: Disturbances of attention are a common behavioral feature associated with neuropsychiatric disorders with largely unknown underlying causes. We previously developed an object-based attention test (OBAT) as a simple and practical method for evaluating attention in mice. Since its establishment, the test has become a popular method for assessing attention and related underlying mechanisms in various mouse models. However, the underlying neuronal network involved in this test has yet to be studied. The purpose of this study was to identify the principal brain regions activated in the OBAT. Accordingly, C57BL/6J mice were subjected to the OBAT and thereafter prepared for immunohistochemical quantification of c-Fos, an immediate early gene that is frequently used as a marker of neuronal activit

SUBMITTER: Wulaer B 

PROVIDER: S-EPMC7737308 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature