Analysis of urinary exosomal metabolites identifies cardiovascular risk signatures with added value to urine analysis.

ABSTRACT:

Background

Subclinical atherosclerosis may result in fatal cardiovascular (CV) events, but the underlying mechanisms and molecular players leading to disease are not entirely understood. Thus, novel approaches capable of identifying the factors involved in pathological progression and providing a better understanding of the subjacent mechanisms are needed. Extracellular vesicles (EVs) have been shown to have numerous biological functions, and their metabolome has recently generated interest as a source of novel biomarkers. The metabolic content of the exosomes has been so far unexplored in cardiovascular disease (CVD), and here, we developed an analytical strategy aimed at probing urinary exosomal metabolite content and its association to CV risk.

Results

Direct analysis of

SUBMITTER: Agudiez M 

PROVIDER: S-EPMC7737341 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature