The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes.

ABSTRACT:

Background

Previous reports from the Management of Myelomeningocele Study demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and the need for cerebrospinal fluid shunting, and improves motor function in children with myelomeningocele. The trial was stopped for efficacy after 183 patients were randomized, but 30-month outcomes were only available at the time of initial publication in 134 mother-child dyads. Data from the complete cohort for the 30-month outcomes are presented here. Maternal and 12-month neurodevelopmental outcomes for the full cohort were reported previously.

Objective

The purpose of this study is to report the 30-month outcomes for the full cohort of patients randomized to either prenatal or postnatal repair of myelomeningocel

SUBMITTER: Farmer DL 

PROVIDER: S-EPMC7737375 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature