Minocycline reduces inflammatory response and cell death in a S100B retina degeneration model.

ABSTRACT:

Background

Previous studies noted that intravitreal injection of S100B triggered a glaucoma-like degeneration of retina and optic nerve as well as microglia activation after 14 days. The precise role of microglia in our intravitreal S100B model is still unclear. Hence, microglia were inhibited through minocycline. The aim is to investigate whether microglia have a significant influence on the degeneration process or whether they are only a side effect in the model studied here.

Methods

Minocycline was applied daily in rats by intraperitoneal injection using two different concentrations (13.5 mg/kg body weight, 25 mg/kg body weight). One day after treatment start, S100B or PBS was intravitreally injected in one eye per rat. The naïve groups received no injections. This result

SUBMITTER: Grotegut P 

PROVIDER: S-EPMC7737388 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature