Adverse Events of the BCG (Bacillus Calmette-Guerin) and Rotavirus Vaccines in a Young Infant with Inborn Error of Immunity.

ABSTRACT:

Background

The Bacillus Calmette-Guérin (BCG) and rotavirus vaccines are live-attenuated preparations. In the United Arab Emirates, these products are universally administered to the young infants. This unguided practice does not account for the children with immunodeficiency, which frequently manifests after the administration of these vaccines. We present here a young infant with immunodeficiency that developed disseminated tuberculosis infection and severe diarrhea due to these improper immunizations. Case Presentation. This young infant was diagnosed at six months of age with "immunodeficiency type 19" (MIM#615617) due to homozygous nonsense variant, NM_000732.4 (CD3D):c.128G > A, p.Trp43∗ (variation ClinVar#VCV000643120.1; pathogenic). This variant creates premat

SUBMITTER: Al-Hammadi S 

PROVIDER: S-EPMC7737464 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature