Ontology highlight
ABSTRACT:
SUBMITTER: Stsiapanava A
PROVIDER: S-EPMC7737619 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20201116 24
Assembly of extracellular filaments and matrices mediating fundamental biological processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven by a ubiquitous polymerization module known as zona pellucida (ZP) "domain". Despite the conservation of this element from hydra to humans, no detailed information is available on the filamentous conformation of any ZP module protein. Here, we report a cryo-electron microscopy study of uromodulin (UMOD)/Tamm-Horsfall protei ...[more]