Potential of Immune-Related Genes as Biomarkers for Diagnosis and Subtype Classification of Preeclampsia.

ABSTRACT:

Objective

Preeclampsia is the main cause of maternal mortality due to a lack of diagnostic biomarkers and effective prevention and treatment. The immune system plays an important role in the occurrence and development of preeclampsia. This research aimed to identify significant immune-related genes to predict preeclampsia and possible prevention and control methods.

Methods

Differential expression analysis between normotensive and PE pregnancies was performed to identify significantly changed immune-related genes. Generalized linear model (GLM), random forest (RF), and support vector machine (SVM) models were established separately to screen the most suitable biomarkers for the diagnosis of PE among these significantly changed immune-related genes. The consensus clustering m

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7737719 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature