Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis.

ABSTRACT:

Background

Approximately 188 million people use cannabis yearly worldwide, and it has recently been legalised in 11 US states, Canada, and Uruguay for recreational use. The potential for increased cannabis use highlights the need to better understand its risks, including the acute induction of psychotic and other psychiatric symptoms. We aimed to investigate the effect of the cannabis constituent Δ⁹-tetrahydrocannabinol (THC) alone and in combination with cannabidiol (CBD) compared with placebo on psychiatric symptoms in healthy people.

Methods

In this systematic review and meta-analysis, we searched MEDLINE, Embase, and PsycINFO for studies published in English between database inception and May 21, 2019, with a within-person, crossover design. Inclusion criteria

SUBMITTER: Hindley G 

PROVIDER: S-EPMC7738353 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature