Multimodal assessment of nigrosomal degeneration in Parkinson's disease.

ABSTRACT:

Background

Approximately forty percent of all dopaminergic neurons in SNpc are located in five dense neuronal clusters, named nigrosomes. T₂- or T₂*-weighted images are used to delineate the largest nigrosome, named nigrosome-1. In these images, nigrosome-1 is a hyperintense region in the caudal and dorsal portion of the T₂- or T₂*-weighted substantia nigra. In PD, nigrosome-1 experiences iron accumulation, which leads to a reduction in T₂-weighted hyperintensity. Here, we examine neuromelanin-depletion and iron deposition in regions of interest (ROIs) derived from quantitative-voxel based morphometry (qVBM) on neuromelanin-sensitive images and compare the ROIs with nigrosome-1 identified in T₂*-weighted images.

M

SUBMITTER: Langley J 

PROVIDER: S-EPMC7738361 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature