Altered Functional Connectivity in White and Gray Matter in Patients With Multiple Sclerosis.

ABSTRACT: Background: Functional magnetic resonance imaging (fMRI) has been widely used to assess neural activity changes in gray matter (GM) in patients with multiple sclerosis (MS); however, brain function alterations in white matter (WM) relatively remain under-explored. Purpose: This work aims to identify the functional connectivity in both the WM and the GM of patients with MS using fMRI and the correlations between these functional changes and cumulative disability as well as the lesion ratio. Materials and Methods: For this retrospective study, 37 patients with clinically definite MS and 43 age-matched healthy controls were included between 2010 and 2014. Resting-state fMRI was performed. The WFU Pick and JHU Eve atlases were used to define 82 GM and 48 WM regions in comm

SUBMITTER: Huang J 

PROVIDER: S-EPMC7738428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature