The human respiratory tract microbial community structures in healthy and cystic fibrosis infants.

ABSTRACT: The metagenome development of the human respiratory tract was investigated by shotgun metagenome metagenomic sequencing of cough swabs from healthy children and children with cystic fibrosis (CF) between 3 weeks and 6 years of age. A healthy microbial community signature was associated with increased absolute abundances in terms of bacterial-human cell ratios of core and rare species across all age groups, with a higher diversity of rare species and a tightly interconnected species co-occurrence network, in which individual members were found in close proximity to each other and negative correlations were absent. Even without typical CF pathogens, the CF infant co-occurrence network was found to be less stable and prone to fragmentation due to fewer connections between species, a higher nu

SUBMITTER: Pust MM 

PROVIDER: S-EPMC7738502 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature