Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response.

ABSTRACT: Patients with neuroendocrine tumors (NETs) can be treated with peptide receptor radionuclide therapy (PRRT). Here, the somatostatin analogue octreotate radiolabeled with lutetium-177 is targeted to NET cells by binding to the somatostatin receptor subtype 2 (SST₂). During radioactive decay, DNA damage is induced, leading to NET cell death. Although the therapy proves to be effective, mortality rates remain high. To appropriately select more optimal treatment strategies, it is essential to first better understand the radiobiological responses of tumor cells to PRRT. Methods: We analyzed PRRT induced radiobiological responses in SST₂ expressing cells and xenografted mice using SPECT/MRI scanning and histological and molecular analyses. We measured [¹⁷⁷

SUBMITTER: Feijtel D 

PROVIDER: S-EPMC7738856 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature