A systematic review of the Trier Social Stress Test methodology: Issues in promoting study comparison and replicable research.

ABSTRACT: Since its development in 1993, the Trier Social Stress Test (TSST) has been used widely as a psychosocial stress paradigm to activate the sympathetic nervous system and hypothalamic-pituitary-adrenal axis (HPAA) stress systems, stimulating physiological functions (e.g. heart rate) and cortisol secretion. Several methodological variations introduced over the years have led the scientific community to question replication between studies. In this systematic review, we used the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) to synthesize procedure-related data available about the TSST protocol to highlight commonalities and differences across studies. We noted significant discrepancies across studies in how researchers applied the TSST protocol. In particular, we h

SUBMITTER: Narvaez Linares NF 

PROVIDER: S-EPMC7739033 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature